Haverford College
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Semester/Topic Title::

Vaccine Development

Additional information/Expanded description:

Biology 362 Vaccines Development
Erik Lamberth
Further papers to be announced



Week 1

Brief History of Vaccines/ Immunology
First Vaccine – cowpox
George Washington and smallpox vaccine
Rates of disease reduction from vaccines

B-Cell, T-Cell, and IgA immune responses
Antigen Load of vaccines
Herd immunity
Non-responders
Booster doses vs. re-vaccination for non-responders
Impact of Vaccination on clinical and laboratory diagnosis of disease, e.g. Hepatitis B, Tuberculosis, and Lyme Disease
Mechanism of Lyme vaccine

Week 2

Keyserling, H. et al, Safety, Immunogenicity, and Immune Memory of a Novel Meningococcal (Groups A, C, Y, and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine (MCV-4) in Healthy Adolescents, Arch Pediatr Adolesc Med. 2005;159:907-913


Vaccine Development
Basics of Clinical Research
Difficulty of getting a single product that is effective for a heterogeneous population
Cost of Development
Ethics of vaccine research, especially for children
Research studies that will never be done due to ethical considerations (e.g. MMR and autism studies)


Week 3

Vaccine preventable illnesses – clinical symptoms
Historical perspectives, e.g. the toll of morbidity and mortality of past scourges
Instances of how these diseases affected history

Week 4

Pichichero, M. et al, Combined Tetanus, Diphtheria, and 5-Component Pertussis Vaccine for Use in Adolescents and Adults, JAMA. 2005;293:3003-3011

Combination vaccines
Conjugate vaccines
Vaccines for cancer, including gardasil for HPV
Future of vaccine development – transdermal vaccine patches, HIV vaccine, smallpox vaccine
DNA Vaccines


Week 5

*GRANT PROPOSALS DUE*


Autism, inflammatory bowel disease, and MMR vaccine
Wakefield A
The Lancet - Vol. 351, Issue 9112, 02 May 1998, Page 1356

Vaccine safety
The VAERS system
How VAERS resulted in the removal of the first rotavirus vaccine (Rotashield)
Side effects of vaccines
Real vs. perceived adverse events
MMR vaccine and autism
Thimerisol
The media’s impact on public perception


Week 6

*GRANT CRITIQUES DUE*

NY Times Essay, Roni Rabin, 7/18/06

Societal reactions to vaccines
Interest in vaccines without a cure
Public reaction to vaccine rationing and shortages
Typical societal reaction to vaccines once disease rates fall
Individuals who refuse vaccines


Week 7

Global Impact
Worlwide distribution of vaccines
US vs Foreign production of vaccines
Legal hurdles of production in the US
WHO and their initiatives to eradicate polio
Why thousands die daily from preventable diseases

Vote on research grants
Discuss topics of student interest